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Midori Shima Selected Research

Factor IX (Coagulation Factor IX)

1/2022F9 mRNA splicing aberration due to a deep Intronic structural variation in a patient with moderate hemophilia B.
12/2021Development of alternative gene transfer techniques for ex vivo and in vivo gene therapy in a canine model.
1/2020Clinical utility and impact of the use of the chromogenic vs one-stage factor activity assays in haemophilia A and B.
1/2016Trends in novel treatments for hemophilia.
7/2015SVA retrotransposition in exon 6 of the coagulation factor IX gene causing severe hemophilia B.
1/2012Hepatocyte Is a Sole Cell Type Responsible for the Production of Coagulation Factor IX In Vivo.
1/2012Human hepatocyte propagation system in the mouse livers: functional maintenance of the production of coagulation and anticoagulation factors.
6/2010Mutant macaque factor IX T262A: a tool for hemophilia B gene therapy studies in macaques.
1/2010Engineering liver tissues under the kidney capsule site provides therapeutic effects to hemophilia B mice.
7/2008Therapeutic effects of hepatocyte transplantation on hemophilia B.
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Midori Shima Research Topics

Disease

99Hemophilia A (Haemophilia)
09/2022 - 03/2002
51Hemorrhage
09/2022 - 03/2004
20Thrombosis (Thrombus)
09/2022 - 06/2002
7Hemophilia B (Haemophilia B)
01/2022 - 05/2008
7Thrombotic Microangiopathies
03/2021 - 09/2016
3Type 3 von Willebrand Disease
09/2022 - 03/2006
3Type 2 von Willebrand Disease
03/2021 - 03/2020
3Myocardial Infarction
01/2021 - 09/2010
3Disseminated Intravascular Coagulation
09/2020 - 06/2018
3Metrorrhagia (Spotting)
01/2020 - 01/2017
3Joint Diseases (Joint Disease)
01/2019 - 06/2011
3Body Weight (Weight, Body)
01/2018 - 11/2009
3Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
06/2016 - 05/2008
3Venous Thrombosis (Deep-Vein Thrombosis)
07/2013 - 05/2010
2Disease Progression
10/2021 - 01/2020
2Sepsis (Septicemia)
09/2020 - 02/2016
2Thromboembolism
01/2020 - 01/2019
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2020 - 07/2014
2Purpura
06/2019 - 12/2013
2von Willebrand Diseases (von Willebrand's Disease)
05/2019 - 02/2015
2Neoplasms (Cancer)
06/2018 - 01/2017
2Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
02/2017 - 01/2017
2Thrombophilia
01/2017 - 06/2013
2Autoimmune Diseases (Autoimmune Disease)
12/2015 - 01/2011
2Pain (Aches)
06/2011 - 01/2007
2Hyperplasia
11/2009 - 12/2008
1COVID-19
01/2022
1Diamond-Blackfan Anemia (Anemia, Diamond Blackfan)
03/2021
1Thrombasthenia (Glanzmann Thrombasthenia)
02/2021
1Intellectual Disability (Idiocy)
11/2020
1Malnutrition (Nutritional Deficiencies)
11/2020
1Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders)
01/2020
1Pulmonary Hypertension
10/2019
1Acute Promyelocytic Leukemia
09/2019
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2019
1Epistaxis (Nosebleed)
09/2019
1Mucocutaneous Lymph Node Syndrome (Kawasaki Disease)
07/2019
1Inflammation (Inflammations)
07/2019
1Protein C Deficiency
06/2019

Drug/Important Bio-Agent (IBA)

55Factor VIII (Coagulation Factor VIII)IBA
09/2022 - 03/2002
33emicizumabIBA
09/2022 - 11/2014
18Hemostatics (Antihemorrhagics)IBA
09/2022 - 01/2004
15von Willebrand FactorIBA
09/2022 - 03/2004
13ThrombinFDA Link
02/2022 - 10/2009
11Factor IX (Coagulation Factor IX)FDA LinkGeneric
01/2022 - 05/2008
11Blood Coagulation Factors (Coagulation Factor)IBA
01/2021 - 01/2007
10FibrinIBA
03/2021 - 10/2009
9AntibodiesIBA
09/2022 - 03/2004
8Thromboplastin (Tissue Factor)IBA
02/2021 - 10/2009
7AutoantibodiesIBA
01/2020 - 02/2006
6prothrombin complex concentrates (PPSB)IBA
03/2021 - 01/2007
6Prothrombin (Factor II)IBA
01/2021 - 04/2009
5FibrinolysinFDA Link
02/2022 - 07/2017
5recombinant FVIIa (rFVIIa)FDA Link
03/2021 - 01/2004
5Monoclonal AntibodiesIBA
01/2021 - 10/2017
5AnticoagulantsIBA
11/2019 - 06/2013
4Immunoglobulin G (IgG)IBA
09/2022 - 03/2004
4CoagulantsIBA
10/2021 - 01/2020
4Factor IXa (Coagulation Factor IXa)IBA
01/2020 - 11/2014
4AntigensIBA
07/2019 - 08/2003
3Heme (Haem)IBA
09/2021 - 01/2019
3Factor VIIIaIBA
03/2021 - 01/2017
3Pharmaceutical PreparationsIBA
11/2020 - 12/2015
3Dacarbazine (DIC)FDA LinkGeneric
09/2020 - 06/2018
3Factor VIIa (Activated Factor VII)IBA
01/2020 - 09/2003
3Factor X (Stuart Factor)IBA
01/2020 - 06/2013
3Ellagic AcidIBA
01/2020 - 12/2009
3Proteins (Proteins, Gene)FDA Link
01/2019 - 01/2012
3Protein CIBA
10/2018 - 06/2013
3Therapeutic UsesIBA
01/2018 - 07/2008
3Protein SIBA
01/2017 - 06/2013
3IsoantibodiesIBA
05/2016 - 02/2006
3Neutralizing AntibodiesIBA
11/2014 - 06/2013
2Bispecific AntibodiesIBA
01/2022 - 05/2020
2Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA
06/2021 - 04/2013
2CollagenIBA
02/2021 - 03/2020
2Asparaginase (Elspar)FDA Link
01/2020 - 01/2017
2AntithrombinsIBA
01/2017 - 06/2013
2lipoprotein-associated coagulation inhibitor (TFPI)IBA
01/2014 - 10/2009
2Factor V (Coagulation Factor V)IBA
12/2013 - 01/2011
2Factor XI (Plasma Thromboplastin Antecedent)IBA
07/2013 - 05/2010
2argatroban (MPQA)FDA Link
07/2013 - 10/2009
2Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
01/2012 - 05/2008
2T-Cell Antigen Receptors (T-Cell Receptor)IBA
12/2011 - 08/2003
2Benzene (Benzole)IBA
11/2009 - 12/2008
2Ethanol (Ethyl Alcohol)IBA
10/2009 - 09/2006
1insulin receptor-related receptor (IRR)IBA
01/2022
1Messenger RNA (mRNA)IBA
01/2022
1Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
10/2019
1Intravenous Immunoglobulins (IVIG)FDA Link
07/2019
1Warfarin (Coumadin)FDA LinkGeneric
06/2019

Therapy/Procedure

38Therapeutics
09/2022 - 08/2003
5Transplantation
03/2021 - 05/2005
5Injections
05/2019 - 10/2012
2Arthrodesis
08/2018 - 06/2011
2Central Venous Catheters
01/2017 - 09/2016
2Intravenous Infusions
05/2016 - 06/2015
2Ligation
02/2016 - 05/2010
2Tooth Extraction (Tooth Extractions)
12/2015 - 03/2006
1Enteral Nutrition (Feeding, Tube)
11/2020